Drug interactions
Bivalirudin + Clopidogrel
Severity: Moderate
Bivalirudin and Clopidogrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor routinely used with clopidogrel during percutaneous coronary intervention. Together they increase bleeding tendency, but the combination is standard practice rather than contraindicated.
What this interaction means in plain words
Bivalirudin and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects of direct thrombin inhibition and P2Y12 platelet inhibition.
What to do
Monitor for bleeding at the access site and systemically, and check hemoglobin as indicated. Limit bivalirudin duration to what the procedure needs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Frequently asked questions
Can I take Bivalirudin with Clopidogrel?
MediHelp rates the interaction as moderate. Bivalirudin and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor routinely used with clopidogrel during percutaneous coronary intervention. Together they increase bleeding tendency, but the combination is standard practice rather than contraindicated.
How serious is the interaction between Bivalirudin and Clopidogrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding at the access site and systemically, and check hemoglobin as indicated. Limit bivalirudin duration to what the procedure needs.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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