Drug interactions
Bivalirudin + Ketoprofen
Severity: Moderate
Bivalirudin and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor, and ketoprofen reduces platelet function and can damage the gastric lining. The combination increases the chance of bleeding.
What this interaction means in plain words
Bivalirudin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment through thrombin inhibition and NSAID platelet inhibition.
What to do
Avoid NSAIDs around bivalirudin use when feasible; monitor for bleeding and hemoglobin if coadministered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Bivalirudin with Ketoprofen?
MediHelp rates the interaction as moderate. Bivalirudin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor, and ketoprofen reduces platelet function and can damage the gastric lining. The combination increases the chance of bleeding.
How serious is the interaction between Bivalirudin and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs around bivalirudin use when feasible; monitor for bleeding and hemoglobin if coadministered.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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