Drug interactions
Bivalirudin + Mifepristone
Severity: Major
Bivalirudin and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor given in acute settings like PCI, and it could increase bleeding after mifepristone-induced abortion. Concurrent use would be rare and only clinically justified in urgent situations.
What this interaction means in plain words
Bivalirudin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effect: anticoagulation on top of expected uterine bleeding.
What to do
Avoid mifepristone while bivalirudin is needed, or defer the abortion if possible. If both are unavoidable, monitor bleeding and hemoglobin closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Bivalirudin with Mifepristone?
MediHelp rates the interaction as major. Bivalirudin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bivalirudin is a direct thrombin inhibitor given in acute settings like PCI, and it could increase bleeding after mifepristone-induced abortion. Concurrent use would be rare and only clinically justified in urgent situations.
How serious is the interaction between Bivalirudin and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid mifepristone while bivalirudin is needed, or defer the abortion if possible. If both are unavoidable, monitor bleeding and hemoglobin closely.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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