Drug interactions
Bivalirudin + Oxaprozin
Severity: Moderate
Bivalirudin and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor, and oxaprozin inhibits platelet function and may cause GI bleeding. The combination increases bleeding risk.
What this interaction means in plain words
Bivalirudin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect between direct thrombin inhibition and NSAID-induced platelet inhibition.
What to do
Avoid starting oxaprozin during bivalirudin therapy where alternatives exist. Monitor for bleeding signs and hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Bivalirudin with Oxaprozin?
MediHelp rates the interaction as moderate. Bivalirudin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor, and oxaprozin inhibits platelet function and may cause GI bleeding. The combination increases bleeding risk.
How serious is the interaction between Bivalirudin and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting oxaprozin during bivalirudin therapy where alternatives exist. Monitor for bleeding signs and hemoglobin.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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