Drug interactions
Bivalirudin + Piperacillin
Severity: Moderate
Bivalirudin and Piperacillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piperacillin can impair platelet function and may add to the bleeding tendency of bivalirudin. The effect is generally modest and can be managed with monitoring.
What this interaction means in plain words
Bivalirudin and Piperacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment through platelet dysfunction from piperacillin plus direct thrombin inhibition.
What to do
Monitor for bleeding and ACT or aPTT as appropriate during bivalirudin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piperacillin
- Piperacillin + Vancomycin Major
- Acetylsalicylic acid + Piperacillin Moderate
- Amikacin + Piperacillin Moderate
- Antithrombin alfa + Piperacillin Moderate
- Antithrombin iii + Piperacillin Moderate
- Argatroban + Piperacillin Moderate
Frequently asked questions
Can I take Bivalirudin with Piperacillin?
MediHelp rates the interaction as moderate. Bivalirudin and Piperacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piperacillin can impair platelet function and may add to the bleeding tendency of bivalirudin. The effect is generally modest and can be managed with monitoring.
How serious is the interaction between Bivalirudin and Piperacillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and ACT or aPTT as appropriate during bivalirudin therapy.
What other medicines interact with Piperacillin?
MediHelp also lists interactions of Piperacillin with, for example, Vancomycin, Acetylsalicylic acid, Amikacin. The full list is on the Piperacillin page.
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