Drug interactions
Bivalirudin + Sulindac
Severity: Moderate
Bivalirudin and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor, and sulindac adds antiplatelet effects and gastrointestinal irritation. The combination raises the risk of bleeding.
What this interaction means in plain words
Bivalirudin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment from direct thrombin inhibition and NSAID platelet inhibition.
What to do
Avoid NSAIDs around bivalirudin therapy where possible. Monitor for bleeding and hemoglobin if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Bivalirudin with Sulindac?
MediHelp rates the interaction as moderate. Bivalirudin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor, and sulindac adds antiplatelet effects and gastrointestinal irritation. The combination raises the risk of bleeding.
How serious is the interaction between Bivalirudin and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs around bivalirudin therapy where possible. Monitor for bleeding and hemoglobin if combined.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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