Drug interactions
Bivalirudin + Vitamin e
Severity: Minor
Bivalirudin and Vitamin e: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor, and high-dose vitamin E has mild antiplatelet effects. The combination could theoretically add to bleeding risk, but this is unlikely at normal vitamin E intakes.
What this interaction means in plain words
Bivalirudin and Vitamin e have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive hemostatic impairment from direct thrombin inhibition and the antiplatelet activity of high-dose vitamin E.
What to do
Avoid megadose vitamin E around bivalirudin use. Monitor for bleeding and clotting time as routinely indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vitamin e
- Betrixaban + Vitamin e Moderate
- Phenindione + Vitamin e Moderate
- Selumetinib + Vitamin e Moderate
- Vitamin e + Warfarin Moderate
- Alfalfa + Vitamin e Minor
- Antithrombin alfa + Vitamin e Minor
Frequently asked questions
Can I take Bivalirudin with Vitamin e?
MediHelp rates the interaction as minor. Bivalirudin and Vitamin e have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bivalirudin is a direct thrombin inhibitor, and high-dose vitamin E has mild antiplatelet effects. The combination could theoretically add to bleeding risk, but this is unlikely at normal vitamin E intakes.
How serious is the interaction between Bivalirudin and Vitamin e?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid megadose vitamin E around bivalirudin use. Monitor for bleeding and clotting time as routinely indicated.
What other medicines interact with Vitamin e?
MediHelp also lists interactions of Vitamin e with, for example, Betrixaban, Phenindione, Selumetinib. The full list is on the Vitamin e page.
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