Drug interactions
Black cohosh + Zidovudine
Severity: Minor
Black cohosh and Zidovudine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Black cohosh has been linked to rare cases of liver injury, and zidovudine can rarely cause hepatotoxicity. The evidence for any combined effect is limited to theoretical concern.
What this interaction means in plain words
Black cohosh and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hepatotoxicity; the mechanism is not well established.
What to do
Avoid black cohosh if possible, and check liver enzymes if symptoms of hepatic injury occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Frequently asked questions
Can I take Black cohosh with Zidovudine?
MediHelp rates the interaction as minor. Black cohosh and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Black cohosh has been linked to rare cases of liver injury, and zidovudine can rarely cause hepatotoxicity. The evidence for any combined effect is limited to theoretical concern.
How serious is the interaction between Black cohosh and Zidovudine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid black cohosh if possible, and check liver enzymes if symptoms of hepatic injury occur.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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