Drug interactions
Blessed thistle + Cimetidine
Severity: Minor
Blessed thistle and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blessed thistle is traditionally said to stimulate gastric acid secretion, which could theoretically oppose acid suppression. No clinical data demonstrate this.
What this interaction means in plain words
Blessed thistle and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic opposition between an acid-stimulating herb and an H2 antagonist.
What to do
Advise patients with reflux or ulcer disease to avoid blessed thistle, and review symptom control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Blessed thistle with Cimetidine?
MediHelp rates the interaction as minor. Blessed thistle and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Blessed thistle is traditionally said to stimulate gastric acid secretion, which could theoretically oppose acid suppression. No clinical data demonstrate this.
How serious is the interaction between Blessed thistle and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients with reflux or ulcer disease to avoid blessed thistle, and review symptom control.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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