Drug interactions
Blinatumomab + Clonidine
Severity: Minor
Blinatumomab and Clonidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blinatumomab causes a transient cytokine release that can suppress CYP450 enzymes. This may temporarily raise concentrations of CYP substrates, but clonidine is only partly metabolized by CYP2D6 and has a wide margin of safety.
What this interaction means in plain words
Blinatumomab and Clonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Blinatumomab belongs to Oncology; Clonidine belongs to Cardiovascular.
Why it happens
Cytokine-mediated transient suppression of hepatic CYP450 activity after blinatumomab infusion starts.
What to do
Monitor blood pressure and heart rate during the first days of each blinatumomab cycle and reduce clonidine if hypotension or bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Blinatumomab
- Blinatumomab + Carbamazepine Moderate
- Blinatumomab + Cyclosporin Moderate
- Blinatumomab + Ethosuximide Moderate
- Blinatumomab + Phenytoin Moderate
- Blinatumomab + Quinidine Moderate
- Blinatumomab + Quinine Moderate
Frequently asked questions
Can I take Blinatumomab with Clonidine?
MediHelp rates the interaction as minor. Blinatumomab and Clonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Blinatumomab causes a transient cytokine release that can suppress CYP450 enzymes. This may temporarily raise concentrations of CYP substrates, but clonidine is only partly metabolized by CYP2D6 and has a wide margin of safety.
How serious is the interaction between Blinatumomab and Clonidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during the first days of each blinatumomab cycle and reduce clonidine if hypotension or bradycardia occurs.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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