Drug interactions
Blinatumomab + Cyclosporin
Severity: Moderate
Blinatumomab and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blinatumomab causes a transient cytokine release at treatment initiation and after dose re-starts, which can temporarily suppress CYP450 activity. Cyclosporine is a narrow therapeutic index CYP3A4 substrate, so its blood concentrations may rise and increase the risk of nephrotoxicity and neurotoxicity.
What this interaction means in plain words
Blinatumomab and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Why it happens
Cytokine release (e.g., IL-6) transiently downregulates CYP450 enzymes, reducing cyclosporine metabolism.
What to do
Monitor cyclosporine trough concentrations and renal function closely during the first days of the first cycle and after re-initiation of blinatumomab. Reduce the cyclosporine dose according to levels and clinical signs of toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Blinatumomab
- Blinatumomab + Carbamazepine Moderate
- Blinatumomab + Ethosuximide Moderate
- Blinatumomab + Phenytoin Moderate
- Blinatumomab + Quinidine Moderate
- Blinatumomab + Quinine Moderate
- Blinatumomab + Siponimod Moderate
Frequently asked questions
Can I take Blinatumomab with Cyclosporin?
MediHelp rates the interaction as moderate. Blinatumomab and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes a transient cytokine release at treatment initiation and after dose re-starts, which can temporarily suppress CYP450 activity. Cyclosporine is a narrow therapeutic index CYP3A4 substrate, so its blood concentrations may rise and increase the risk of nephrotoxicity and neurotoxicity.
How serious is the interaction between Blinatumomab and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations and renal function closely during the first days of the first cycle and after re-initiation of blinatumomab. Reduce the cyclosporine dose according to levels and clinical signs of toxicity.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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