Drug interactions
Blinatumomab + Theophylline
Severity: Moderate
Blinatumomab and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blinatumomab causes a transient cytokine release at treatment start that can suppress CYP450 enzymes. Theophylline, a narrow therapeutic index CYP1A2 substrate, may accumulate and cause toxicity such as tachyarrhythmia, nausea or seizures.
What this interaction means in plain words
Blinatumomab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Theophylline belongs to Respiratory.
Why it happens
Cytokine-mediated transient suppression of hepatic CYP450 enzymes (including CYP1A2) reduces theophylline clearance.
What to do
Monitor theophylline serum levels and signs of toxicity during the first days of the first cycle and when restarting after an interruption. Reduce the theophylline dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Blinatumomab
- Blinatumomab + Carbamazepine Moderate
- Blinatumomab + Cyclosporin Moderate
- Blinatumomab + Ethosuximide Moderate
- Blinatumomab + Phenytoin Moderate
- Blinatumomab + Quinidine Moderate
- Blinatumomab + Quinine Moderate
Frequently asked questions
Can I take Blinatumomab with Theophylline?
MediHelp rates the interaction as moderate. Blinatumomab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes a transient cytokine release at treatment start that can suppress CYP450 enzymes. Theophylline, a narrow therapeutic index CYP1A2 substrate, may accumulate and cause toxicity such as tachyarrhythmia, nausea or seizures.
How serious is the interaction between Blinatumomab and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum levels and signs of toxicity during the first days of the first cycle and when restarting after an interruption. Reduce the theophylline dose if levels rise.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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