Drug interactions
Boceprevir + Mifepristone
Severity: Major
Boceprevir and Mifepristone: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boceprevir, a strong CYP3A4 inhibitor, can raise mifepristone exposure, increasing dose-related effects such as hypokalemia, adrenal insufficiency symptoms and QT prolongation.
What this interaction means in plain words
Boceprevir and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Boceprevir belongs to Anti Virals; Mifepristone belongs to Endocrine.
Why it happens
Boceprevir inhibits CYP3A4, the main metabolic pathway of mifepristone.
What to do
For Cushing syndrome keep the mifepristone dose at or below 300 mg daily and monitor potassium, ECG and adrenal insufficiency symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Boceprevir with Mifepristone?
MediHelp rates the interaction as major. Boceprevir and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Boceprevir, a strong CYP3A4 inhibitor, can raise mifepristone exposure, increasing dose-related effects such as hypokalemia, adrenal insufficiency symptoms and QT prolongation.
How serious is the interaction between Boceprevir and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For Cushing syndrome keep the mifepristone dose at or below 300 mg daily and monitor potassium, ECG and adrenal insufficiency symptoms.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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