Drug interactions
Bosentan + Budesonide
Severity: Moderate
Bosentan and Budesonide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and can reduce systemic exposure to budesonide, potentially lowering its therapeutic effect. The effect is most relevant for oral budesonide.
What this interaction means in plain words
Bosentan and Budesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Budesonide belongs to Respiratory.
Why it happens
Bosentan induces CYP3A4, accelerating budesonide metabolism.
What to do
Monitor for reduced efficacy of budesonide and adjust the dose if disease control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Budesonide?
MediHelp rates the interaction as moderate. Bosentan and Budesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and can reduce systemic exposure to budesonide, potentially lowering its therapeutic effect. The effect is most relevant for oral budesonide.
How serious is the interaction between Bosentan and Budesonide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy of budesonide and adjust the dose if disease control worsens.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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