Drug interactions
Bosentan + Buprenorphine long-acting
Severity: Moderate
Bosentan and Buprenorphine long-acting: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower buprenorphine concentrations from the long-acting injection, risking withdrawal or relapse.
What this interaction means in plain words
Bosentan and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bosentan induces CYP3A4, increasing buprenorphine clearance.
What to do
Monitor for withdrawal and adequacy of buprenorphine effect; if inadequate, transition to a buprenorphine formulation that allows dose adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Buprenorphine long-acting?
MediHelp rates the interaction as moderate. Bosentan and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may lower buprenorphine concentrations from the long-acting injection, risking withdrawal or relapse.
How serious is the interaction between Bosentan and Buprenorphine long-acting?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal and adequacy of buprenorphine effect; if inadequate, transition to a buprenorphine formulation that allows dose adjustment.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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