Drug interactions
Bosentan + Buprenorphine subdermal implant
Severity: Moderate
Bosentan and Buprenorphine subdermal implant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce buprenorphine concentrations from the implant, leading to withdrawal symptoms or loss of efficacy. The implant dose cannot be adjusted.
What this interaction means in plain words
Bosentan and Buprenorphine subdermal implant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bosentan induces CYP3A4, increasing buprenorphine metabolism.
What to do
Monitor for withdrawal and cravings; if bosentan cannot be avoided and symptoms occur, remove the implant and switch to an adjustable buprenorphine formulation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Buprenorphine subdermal implant?
MediHelp rates the interaction as moderate. Bosentan and Buprenorphine subdermal implant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce buprenorphine concentrations from the implant, leading to withdrawal symptoms or loss of efficacy. The implant dose cannot be adjusted.
How serious is the interaction between Bosentan and Buprenorphine subdermal implant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal and cravings; if bosentan cannot be avoided and symptoms occur, remove the implant and switch to an adjustable buprenorphine formulation.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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