Drug interactions
Bosentan + Butabarbital
Severity: Moderate
Bosentan and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and CYP2C9 and may lower bosentan concentrations, reducing efficacy in pulmonary arterial hypertension. Bosentan may in turn lower barbiturate effect.
What this interaction means in plain words
Bosentan and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Butabarbital induces CYP2C9 and CYP3A4, increasing bosentan metabolism.
What to do
Monitor clinical response and exercise tolerance of PAH; consider an alternative sedative if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Butabarbital?
MediHelp rates the interaction as moderate. Bosentan and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and CYP2C9 and may lower bosentan concentrations, reducing efficacy in pulmonary arterial hypertension. Bosentan may in turn lower barbiturate effect.
How serious is the interaction between Bosentan and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and exercise tolerance of PAH; consider an alternative sedative if efficacy declines.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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