Drug interactions
Bosentan + Cabozantinib
Severity: Moderate
Bosentan and Cabozantinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may reduce cabozantinib plasma concentrations. Lower exposure could reduce antitumour efficacy.
What this interaction means in plain words
Bosentan and Cabozantinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Cabozantinib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, increasing cabozantinib clearance.
What to do
Avoid the combination if possible. If bosentan is required, monitor for loss of efficacy and consider cabozantinib dose adjustment per product labeling, reducing the dose again after bosentan is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Cabozantinib
Frequently asked questions
Can I take Bosentan with Cabozantinib?
MediHelp rates the interaction as moderate. Bosentan and Cabozantinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and may reduce cabozantinib plasma concentrations. Lower exposure could reduce antitumour efficacy.
How serious is the interaction between Bosentan and Cabozantinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If bosentan is required, monitor for loss of efficacy and consider cabozantinib dose adjustment per product labeling, reducing the dose again after bosentan is stopped.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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