Drug interactions
Bosentan + Cannabidiol
Severity: Moderate
Bosentan and Cannabidiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may inhibit CYP2C9 and CYP3A4 and thereby increase bosentan exposure. This could raise the risk of hepatotoxicity, edema and anemia.
What this interaction means in plain words
Bosentan and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Cannabidiol belongs to Central Nervous System.
Why it happens
Cannabidiol inhibits CYP2C9 and possibly CYP3A4, reducing bosentan metabolism; cannabidiol itself is also hepatotoxic.
What to do
Monitor liver aminotransferases and hemoglobin closely, and reduce bosentan dose if hepatic or other adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Tacrolimus Major
- Cannabidiol + Valproic acid Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Bosentan with Cannabidiol?
MediHelp rates the interaction as moderate. Bosentan and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol may inhibit CYP2C9 and CYP3A4 and thereby increase bosentan exposure. This could raise the risk of hepatotoxicity, edema and anemia.
How serious is the interaction between Bosentan and Cannabidiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver aminotransferases and hemoglobin closely, and reduce bosentan dose if hepatic or other adverse effects emerge.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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