Drug interactions
Bosentan + Carvedilol
Severity: Minor
Bosentan and Carvedilol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a CYP2C9 and CYP3A4 inducer and may lower carvedilol exposure. The clinical effect is probably modest.
What this interaction means in plain words
Bosentan and Carvedilol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Carvedilol belongs to Cardiovascular.
Why it happens
Bosentan induction of hepatic enzymes increases carvedilol metabolism.
What to do
Monitor blood pressure and heart rate and adjust the carvedilol dose if response weakens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Carvedilol?
MediHelp rates the interaction as minor. Bosentan and Carvedilol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a CYP2C9 and CYP3A4 inducer and may lower carvedilol exposure. The clinical effect is probably modest.
How serious is the interaction between Bosentan and Carvedilol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust the carvedilol dose if response weakens.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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