Drug interactions
Bosentan + Ceftobiprole medocaril
Severity: Moderate
Bosentan and Ceftobiprole medocaril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits hepatic uptake transporters OATP1B1 and OATP1B3, which carry bosentan into the liver. Bosentan concentrations may rise, increasing the risk of hepatotoxicity and other dose-related adverse effects.
What this interaction means in plain words
Bosentan and Ceftobiprole medocaril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of bosentan by ceftobiprole.
What to do
Monitor liver aminotransferases and for signs of bosentan toxicity such as hypotension and edema during the short antibiotic course. Consider an alternative antibiotic if liver function is already abnormal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bosentan and Ceftobiprole medocaril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Ceftobiprole medocaril?
MediHelp rates the interaction as moderate. Bosentan and Ceftobiprole medocaril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftobiprole inhibits hepatic uptake transporters OATP1B1 and OATP1B3, which carry bosentan into the liver. Bosentan concentrations may rise, increasing the risk of hepatotoxicity and other dose-related adverse effects.
How serious is the interaction between Bosentan and Ceftobiprole medocaril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver aminotransferases and for signs of bosentan toxicity such as hypotension and edema during the short antibiotic course. Consider an alternative antibiotic if liver function is already abnormal.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
