Drug interactions
Bosentan + Cenobamate
Severity: Moderate
Bosentan and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower bosentan exposure, potentially reducing efficacy in pulmonary arterial hypertension.
What this interaction means in plain words
Bosentan and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Cenobamate belongs to Central Nervous System.
Why it happens
Cenobamate induces CYP3A4 (and CYP2B6), increasing bosentan clearance.
What to do
Monitor clinical response of pulmonary hypertension and increase the bosentan dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Bosentan with Cenobamate?
MediHelp rates the interaction as moderate. Bosentan and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower bosentan exposure, potentially reducing efficacy in pulmonary arterial hypertension.
How serious is the interaction between Bosentan and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response of pulmonary hypertension and increase the bosentan dose if needed.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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