Drug interactions
Bosentan + Chlordiazepoxide
Severity: Minor
Bosentan and Chlordiazepoxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may reduce chlordiazepoxide concentrations, potentially weakening anxiolytic or withdrawal-suppressing effect. The clinical impact is expected to be modest.
What this interaction means in plain words
Bosentan and Chlordiazepoxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Chlordiazepoxide belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by bosentan increases hepatic metabolism of chlordiazepoxide.
What to do
Monitor clinical response to chlordiazepoxide after bosentan is started and increase the dose only if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Chlordiazepoxide?
MediHelp rates the interaction as minor. Bosentan and Chlordiazepoxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a moderate CYP3A4 inducer and may reduce chlordiazepoxide concentrations, potentially weakening anxiolytic or withdrawal-suppressing effect. The clinical impact is expected to be modest.
How serious is the interaction between Bosentan and Chlordiazepoxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to chlordiazepoxide after bosentan is started and increase the dose only if efficacy is lost.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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