Drug interactions
Bosentan + Cortisone
Severity: Moderate
Bosentan and Cortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower corticosteroid exposure through CYP3A4 induction. Cortisone is a prodrug converted to cortisol, and reduced effect could matter in adrenal insufficiency.
What this interaction means in plain words
Bosentan and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bosentan induces CYP3A4, increasing corticosteroid clearance.
What to do
Monitor for loss of glucocorticoid effect or signs of adrenal insufficiency and increase the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Cortisone?
MediHelp rates the interaction as moderate. Bosentan and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may lower corticosteroid exposure through CYP3A4 induction. Cortisone is a prodrug converted to cortisol, and reduced effect could matter in adrenal insufficiency.
How serious is the interaction between Bosentan and Cortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of glucocorticoid effect or signs of adrenal insufficiency and increase the dose if needed.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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