Drug interactions
Bosentan + Danazol
Severity: Moderate
Bosentan and Danazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and may raise bosentan concentrations. Danazol itself can cause liver enzyme elevation, so the combined hepatotoxicity risk is a concern.
What this interaction means in plain words
Bosentan and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4, reducing bosentan clearance, with additive hepatotoxic potential.
What to do
Monitor liver aminotransferases more frequently and watch for hypotension, edema and anemia. Reduce or stop one agent if liver enzymes rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Danazol?
MediHelp rates the interaction as moderate. Bosentan and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak CYP3A4 inhibitor and may raise bosentan concentrations. Danazol itself can cause liver enzyme elevation, so the combined hepatotoxicity risk is a concern.
How serious is the interaction between Bosentan and Danazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver aminotransferases more frequently and watch for hypotension, edema and anemia. Reduce or stop one agent if liver enzymes rise.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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