Drug interactions
Bosentan + Deferasirox
Severity: Moderate
Bosentan and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce CYP3A4 and CYP2C8 variably and may lower bosentan exposure. Reduced bosentan levels may weaken control of pulmonary arterial hypertension.
What this interaction means in plain words
Bosentan and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Deferasirox belongs to Miscellaneous.
Why it happens
Deferasirox may modulate CYP3A4 and CYP2C9 metabolism of bosentan, with the direction of effect not firmly established.
What to do
Monitor clinical response and functional status of pulmonary hypertension when starting or stopping deferasirox. Adjust the bosentan dose if efficacy changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferasirox
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Deferasirox?
MediHelp rates the interaction as moderate. Bosentan and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can induce CYP3A4 and CYP2C8 variably and may lower bosentan exposure. Reduced bosentan levels may weaken control of pulmonary arterial hypertension.
How serious is the interaction between Bosentan and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and functional status of pulmonary hypertension when starting or stopping deferasirox. Adjust the bosentan dose if efficacy changes.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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