Drug interactions
Bosentan + Delavirdine
Severity: Major
Bosentan and Delavirdine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Delavirdine is a CYP3A4 inhibitor and is expected to raise bosentan levels, raising the risk of hepatotoxicity and hypotension. Bosentan may also lower delavirdine levels, risking antiviral failure.
What this interaction means in plain words
Bosentan and Delavirdine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Delavirdine inhibits CYP3A4 metabolism of bosentan while bosentan induces CYP3A4, affecting delavirdine.
What to do
Avoid the combination and choose another antiretroviral. If unavoidable, monitor liver tests, blood pressure and HIV viral load closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Delavirdine?
MediHelp rates the interaction as major. Bosentan and Delavirdine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Delavirdine is a CYP3A4 inhibitor and is expected to raise bosentan levels, raising the risk of hepatotoxicity and hypotension. Bosentan may also lower delavirdine levels, risking antiviral failure.
How serious is the interaction between Bosentan and Delavirdine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antiretroviral. If unavoidable, monitor liver tests, blood pressure and HIV viral load closely.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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