Drug interactions
Bosentan + Dexamethasone-tobramycin
Severity: Moderate
Bosentan and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may reduce dexamethasone exposure and effect. Dexamethasone may in turn alter bosentan levels, as bosentan is a CYP3A4 substrate.
What this interaction means in plain words
Bosentan and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Bosentan induces CYP3A4, increasing dexamethasone clearance.
What to do
Monitor corticosteroid response and increase the dexamethasone dose if effect is inadequate. Monitor bosentan efficacy and liver function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Bosentan and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and may reduce dexamethasone exposure and effect. Dexamethasone may in turn alter bosentan levels, as bosentan is a CYP3A4 substrate.
How serious is the interaction between Bosentan and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor corticosteroid response and increase the dexamethasone dose if effect is inadequate. Monitor bosentan efficacy and liver function.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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