Drug interactions
Bosentan + Diazepam intranasal
Severity: Moderate
Bosentan and Diazepam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may speed diazepam elimination, potentially reducing seizure control. The effect is likely modest given bosentan is a moderate inducer.
What this interaction means in plain words
Bosentan and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bosentan induces CYP3A4 (and possibly CYP2C19), increasing diazepam metabolism.
What to do
Monitor seizure control and sedation response; a repeat dose or alternative rescue therapy may be needed if efficacy is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Diazepam intranasal?
MediHelp rates the interaction as moderate. Bosentan and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may speed diazepam elimination, potentially reducing seizure control. The effect is likely modest given bosentan is a moderate inducer.
How serious is the interaction between Bosentan and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation response; a repeat dose or alternative rescue therapy may be needed if efficacy is inadequate.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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