Drug interactions
Bosentan + Disulfiram
Severity: Minor
Bosentan and Disulfiram: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram inhibits some CYP enzymes, including CYP2C9, and may raise bosentan concentrations. This could increase dose-related effects such as hepatotoxicity.
What this interaction means in plain words
Bosentan and Disulfiram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Disulfiram may inhibit CYP2C9-mediated bosentan metabolism.
What to do
Monitor liver function tests as per bosentan labeling, with extra attention during disulfiram therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Disulfiram?
MediHelp rates the interaction as minor. Bosentan and Disulfiram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Disulfiram inhibits some CYP enzymes, including CYP2C9, and may raise bosentan concentrations. This could increase dose-related effects such as hepatotoxicity.
How serious is the interaction between Bosentan and Disulfiram?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests as per bosentan labeling, with extra attention during disulfiram therapy.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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