Drug interactions
Bosentan + Doxorubicin
Severity: Minor
Bosentan and Doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and might lower doxorubicin exposure. Doxorubicin is mainly cleared by carbonyl reductase and transporters, so CYP3A4 plays a minor role and any effect is probably small. No clinically meaningful interaction is established.
What this interaction means in plain words
Bosentan and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Doxorubicin belongs to Oncology.
Why it happens
Theoretical CYP3A4 induction by bosentan; CYP3A4 is a minor route for doxorubicin.
What to do
No routine adjustment is needed; monitor clinical response to chemotherapy as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Doxorubicin?
MediHelp rates the interaction as minor. Bosentan and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a moderate CYP3A4 inducer and might lower doxorubicin exposure. Doxorubicin is mainly cleared by carbonyl reductase and transporters, so CYP3A4 plays a minor role and any effect is probably small. No clinically meaningful interaction is established.
How serious is the interaction between Bosentan and Doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor clinical response to chemotherapy as usual.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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