Drug interactions
Bosentan + Ethosuximide
Severity: Moderate
Bosentan and Ethosuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethosuximide is partly metabolised by CYP3A4, and bosentan is a moderate CYP3A4 inducer that may lower ethosuximide levels. This could reduce control of absence seizures.
What this interaction means in plain words
Bosentan and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Ethosuximide belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by bosentan increases ethosuximide metabolism.
What to do
Monitor seizure control and consider ethosuximide serum concentrations after bosentan is started or stopped, adjusting the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Ethosuximide?
MediHelp rates the interaction as moderate. Bosentan and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethosuximide is partly metabolised by CYP3A4, and bosentan is a moderate CYP3A4 inducer that may lower ethosuximide levels. This could reduce control of absence seizures.
How serious is the interaction between Bosentan and Ethosuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and consider ethosuximide serum concentrations after bosentan is started or stopped, adjusting the dose as needed.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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