Drug interactions
Bosentan + Fentanyl transdermal
Severity: Moderate
Bosentan and Fentanyl transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce fentanyl exposure, leading to reduced analgesia or withdrawal. When bosentan is stopped, fentanyl levels may rise and cause respiratory depression.
What this interaction means in plain words
Bosentan and Fentanyl transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bosentan induces CYP3A4, increasing fentanyl metabolism.
What to do
Monitor analgesia and withdrawal on starting bosentan and for sedation and respiratory depression on stopping it; adjust the patch dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Fentanyl transdermal?
MediHelp rates the interaction as moderate. Bosentan and Fentanyl transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce fentanyl exposure, leading to reduced analgesia or withdrawal. When bosentan is stopped, fentanyl levels may rise and cause respiratory depression.
How serious is the interaction between Bosentan and Fentanyl transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesia and withdrawal on starting bosentan and for sedation and respiratory depression on stopping it; adjust the patch dose accordingly.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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