Drug interactions
Bosentan + Flurazepam
Severity: Minor
Bosentan and Flurazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower exposure to flurazepam and its active metabolite through CYP3A4 induction. The sedative effect could be weaker than expected.
What this interaction means in plain words
Bosentan and Flurazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Bosentan induces CYP3A4, increasing metabolism of flurazepam.
What to do
Monitor hypnotic effect and increase the flurazepam dose only if clinically needed; consider an alternative hypnotic if effect is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Flurazepam?
MediHelp rates the interaction as minor. Bosentan and Flurazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan may lower exposure to flurazepam and its active metabolite through CYP3A4 induction. The sedative effect could be weaker than expected.
How serious is the interaction between Bosentan and Flurazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hypnotic effect and increase the flurazepam dose only if clinically needed; consider an alternative hypnotic if effect is lost.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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