Drug interactions
Bosentan + Griseofulvin
Severity: Moderate
Bosentan and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may lower bosentan concentrations. Reduced control of pulmonary arterial hypertension is possible.
What this interaction means in plain words
Bosentan and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Griseofulvin belongs to Anti Fungals.
Why it happens
Induction of CYP3A4 and CYP2C9 by griseofulvin increases bosentan clearance.
What to do
Monitor symptoms and functional status of pulmonary hypertension, and consider alternative antifungal therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Griseofulvin?
MediHelp rates the interaction as moderate. Bosentan and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may lower bosentan concentrations. Reduced control of pulmonary arterial hypertension is possible.
How serious is the interaction between Bosentan and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptoms and functional status of pulmonary hypertension, and consider alternative antifungal therapy.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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