Drug interactions
Bosentan + Hydroxyprogesterone caproate
Severity: Minor
Bosentan and Hydroxyprogesterone caproate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce exposure to hydroxyprogesterone caproate through CYP3A4 induction. The therapeutic effect of the progestin may be reduced.
What this interaction means in plain words
Bosentan and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Bosentan induces CYP3A4, increasing progestin metabolism.
What to do
Monitor for reduced progestin efficacy and adjust therapy if clinical response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Hydroxyprogesterone caproate?
MediHelp rates the interaction as minor. Bosentan and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan may reduce exposure to hydroxyprogesterone caproate through CYP3A4 induction. The therapeutic effect of the progestin may be reduced.
How serious is the interaction between Bosentan and Hydroxyprogesterone caproate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced progestin efficacy and adjust therapy if clinical response is inadequate.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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