Drug interactions
Bosentan + Isoniazid
Severity: Moderate
Bosentan and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak CYP3A4 inhibitor and may modestly raise bosentan concentrations. Both drugs are hepatotoxic, so the combination may increase the risk of liver injury.
What this interaction means in plain words
Bosentan and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak CYP3A4 inhibition by isoniazid plus additive hepatotoxicity.
What to do
Monitor liver aminotransferases and bilirubin more frequently during co-therapy. Reduce or stop either drug if liver enzymes rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Isoniazid?
MediHelp rates the interaction as moderate. Bosentan and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid is a weak CYP3A4 inhibitor and may modestly raise bosentan concentrations. Both drugs are hepatotoxic, so the combination may increase the risk of liver injury.
How serious is the interaction between Bosentan and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver aminotransferases and bilirubin more frequently during co-therapy. Reduce or stop either drug if liver enzymes rise significantly.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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