Drug interactions
Bosentan + Ixabepilone
Severity: Moderate
Bosentan and Ixabepilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixabepilone is mainly metabolised by CYP3A4, so bosentan may lower its exposure and reduce antitumour efficacy. Effect size has not been well characterised for moderate inducers.
What this interaction means in plain words
Bosentan and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bosentan induces CYP3A4, increasing ixabepilone clearance.
What to do
Monitor oncologic response and consider an alternative to bosentan; strong inducers need dose adjustment per labeling, but moderate inducers do not have a defined recommendation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Ixabepilone?
MediHelp rates the interaction as moderate. Bosentan and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ixabepilone is mainly metabolised by CYP3A4, so bosentan may lower its exposure and reduce antitumour efficacy. Effect size has not been well characterised for moderate inducers.
How serious is the interaction between Bosentan and Ixabepilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor oncologic response and consider an alternative to bosentan; strong inducers need dose adjustment per labeling, but moderate inducers do not have a defined recommendation.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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