Drug interactions
Bosentan + Levonorgestrel intrauterine
Severity: Minor
Bosentan and Levonorgestrel intrauterine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intrauterine levonorgestrel system acts mainly locally with low systemic levels, so CYP3A4 induction by bosentan is unlikely to matter much for contraception. The effect on systemic progestin exposure is small.
What this interaction means in plain words
Bosentan and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Bosentan induces CYP3A4, which may modestly lower systemic levonorgestrel, but local endometrial action predominates.
What to do
No routine change needed; note that bosentan is teratogenic, so reliable contraception is required, and the intrauterine system is an acceptable option.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Levonorgestrel intrauterine?
MediHelp rates the interaction as minor. Bosentan and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The intrauterine levonorgestrel system acts mainly locally with low systemic levels, so CYP3A4 induction by bosentan is unlikely to matter much for contraception. The effect on systemic progestin exposure is small.
How serious is the interaction between Bosentan and Levonorgestrel intrauterine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed; note that bosentan is teratogenic, so reliable contraception is required, and the intrauterine system is an acceptable option.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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