Drug interactions
Bosentan + Pentobarbital
Severity: Moderate
Bosentan and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are enzyme inducers and can lower bosentan exposure, which may reduce its effect on pulmonary arterial pressure. Bosentan is itself an inducer, so the net change is hard to predict and clinical data with pentobarbital are limited.
What this interaction means in plain words
Bosentan and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pentobarbital induces CYP3A4 and CYP2C9, the main enzymes that metabolize bosentan, increasing its clearance.
What to do
Monitor clinical response in pulmonary arterial hypertension (functional class, symptoms) when starting or stopping pentobarbital. Consider an alternative sedative if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Pentobarbital?
MediHelp rates the interaction as moderate. Bosentan and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are enzyme inducers and can lower bosentan exposure, which may reduce its effect on pulmonary arterial pressure. Bosentan is itself an inducer, so the net change is hard to predict and clinical data with pentobarbital are limited.
How serious is the interaction between Bosentan and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response in pulmonary arterial hypertension (functional class, symptoms) when starting or stopping pentobarbital. Consider an alternative sedative if efficacy declines.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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