Drug interactions
Bosentan + Progesterone micronized
Severity: Moderate
Bosentan and Progesterone micronized: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral micronized progesterone undergoes extensive CYP3A4 metabolism, and induction by bosentan may reduce its exposure. This may lead to inadequate endometrial protection or hormonal effect.
What this interaction means in plain words
Bosentan and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bosentan induces CYP3A4, increasing progesterone first-pass and systemic metabolism.
What to do
Monitor for breakthrough bleeding or loss of effect and consider a higher progesterone dose or an alternative route.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Progesterone micronized?
MediHelp rates the interaction as moderate. Bosentan and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral micronized progesterone undergoes extensive CYP3A4 metabolism, and induction by bosentan may reduce its exposure. This may lead to inadequate endometrial protection or hormonal effect.
How serious is the interaction between Bosentan and Progesterone micronized?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough bleeding or loss of effect and consider a higher progesterone dose or an alternative route.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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