Drug interactions
Bosentan + Quinupristin / dalfopristin
Severity: Moderate
Bosentan and Quinupristin / dalfopristin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise bosentan concentrations. Higher bosentan exposure increases the risk of hepatotoxicity, headache, edema and hypotension. Use is typically short-term and clinical data are limited.
What this interaction means in plain words
Bosentan and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, reducing bosentan metabolism.
What to do
Monitor liver aminotransferases and for signs of bosentan toxicity such as hypotension and edema during the antibiotic course. Choose another antibiotic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Bosentan and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may raise bosentan concentrations. Higher bosentan exposure increases the risk of hepatotoxicity, headache, edema and hypotension. Use is typically short-term and clinical data are limited.
How serious is the interaction between Bosentan and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver aminotransferases and for signs of bosentan toxicity such as hypotension and edema during the antibiotic course. Choose another antibiotic if feasible.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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