Drug interactions
Bosentan + Rabeprazole
Severity: Minor
Bosentan and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a modest CYP3A4 and CYP2C9 inducer and could slightly lower rabeprazole levels, though rabeprazole's largely non-enzymatic clearance limits this effect.
What this interaction means in plain words
Bosentan and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Bosentan induces CYP3A4, potentially increasing rabeprazole metabolism.
What to do
No routine adjustment is needed; reassess acid suppression if symptoms persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Rabeprazole?
MediHelp rates the interaction as minor. Bosentan and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a modest CYP3A4 and CYP2C9 inducer and could slightly lower rabeprazole levels, though rabeprazole's largely non-enzymatic clearance limits this effect.
How serious is the interaction between Bosentan and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess acid suppression if symptoms persist.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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