Drug interactions
Bosentan + Teniposide
Severity: Moderate
Bosentan and Teniposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teniposide is metabolized by CYP3A4, so bosentan induction could lower its concentrations and reduce antineoplastic effect.
What this interaction means in plain words
Bosentan and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bosentan induces CYP3A4, increasing the metabolism of teniposide.
What to do
Monitor the response to chemotherapy and for reduced efficacy. Consider alternatives if the combination is not essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Teniposide?
MediHelp rates the interaction as moderate. Bosentan and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teniposide is metabolized by CYP3A4, so bosentan induction could lower its concentrations and reduce antineoplastic effect.
How serious is the interaction between Bosentan and Teniposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the response to chemotherapy and for reduced efficacy. Consider alternatives if the combination is not essential.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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