Drug interactions
Bosentan + Theophylline
Severity: Minor
Bosentan and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces some CYP enzymes and could lower theophylline concentrations. Because CYP3A4 is a minor pathway for theophylline, the effect is likely small and unpredictable.
What this interaction means in plain words
Bosentan and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Theophylline belongs to Respiratory.
Why it happens
Bosentan induces CYP3A4 and CYP2C9, which may modestly increase theophylline clearance.
What to do
Monitor clinical response and check theophylline levels if control of respiratory symptoms worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Theophylline?
MediHelp rates the interaction as minor. Bosentan and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces some CYP enzymes and could lower theophylline concentrations. Because CYP3A4 is a minor pathway for theophylline, the effect is likely small and unpredictable.
How serious is the interaction between Bosentan and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and check theophylline levels if control of respiratory symptoms worsens.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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