Drug interactions
Bosutinib + Carvedilol
Severity: Moderate
Bosutinib and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol inhibits P-glycoprotein and may increase bosutinib exposure, with greater gastrointestinal, hepatic and myelosuppressive toxicity. The size of the effect is uncertain.
What this interaction means in plain words
Bosutinib and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Carvedilol belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux, reducing bosutinib clearance.
What to do
Monitor for bosutinib adverse effects, including diarrhea and liver enzyme elevations. Reduce the bosutinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Carvedilol?
MediHelp rates the interaction as moderate. Bosutinib and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol inhibits P-glycoprotein and may increase bosutinib exposure, with greater gastrointestinal, hepatic and myelosuppressive toxicity. The size of the effect is uncertain.
How serious is the interaction between Bosutinib and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bosutinib adverse effects, including diarrhea and liver enzyme elevations. Reduce the bosutinib dose if toxicity occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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