Drug interactions
Bosentan + Bosutinib
Severity: Major
Bosentan and Bosutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower bosutinib exposure through CYP3A4 induction, risking loss of efficacy in CML. Bosutinib labeling advises avoiding moderate and strong CYP3A inducers.
What this interaction means in plain words
Bosentan and Bosutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Bosutinib belongs to Oncology.
Why it happens
CYP3A4 induction by bosentan increases bosutinib clearance.
What to do
Avoid concomitant use and select an alternative to bosentan if possible. If unavoidable, monitor hematologic and molecular response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
- Bosutinib + Cisapride Major
Frequently asked questions
Can I take Bosentan with Bosutinib?
MediHelp rates the interaction as major. Bosentan and Bosutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan may lower bosutinib exposure through CYP3A4 induction, risking loss of efficacy in CML. Bosutinib labeling advises avoiding moderate and strong CYP3A inducers.
How serious is the interaction between Bosentan and Bosutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select an alternative to bosentan if possible. If unavoidable, monitor hematologic and molecular response closely.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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