Drug interactions
Amiodarone + Bosutinib
Severity: Major
Amiodarone and Bosutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP3A4 and P-glycoprotein and may raise bosutinib concentrations, increasing gastrointestinal, hepatic and hematologic toxicity. Both drugs may also affect QT interval.
What this interaction means in plain words
Amiodarone and Bosutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Bosutinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by amiodarone, with possible additive QT effects.
What to do
Avoid the combination if possible. If used, monitor liver tests, blood counts, ECG and bosutinib adverse effects and consider dose reduction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Bosutinib
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
- Bosutinib + Cisapride Major
Frequently asked questions
Can I take Amiodarone with Bosutinib?
MediHelp rates the interaction as major. Amiodarone and Bosutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone inhibits CYP3A4 and P-glycoprotein and may raise bosutinib concentrations, increasing gastrointestinal, hepatic and hematologic toxicity. Both drugs may also affect QT interval.
How serious is the interaction between Amiodarone and Bosutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor liver tests, blood counts, ECG and bosutinib adverse effects and consider dose reduction.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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