Drug interactions
Bosutinib + Diltiazem
Severity: Major
Bosutinib and Diltiazem: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib is a CYP3A4 substrate, and diltiazem is a moderate CYP3A4 inhibitor. Higher bosutinib levels raise the risk of hepatotoxicity, gastrointestinal toxicity and myelosuppression.
What this interaction means in plain words
Bosutinib and Diltiazem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Diltiazem belongs to Cardiovascular.
Why it happens
Diltiazem inhibits CYP3A4-mediated metabolism of bosutinib.
What to do
Avoid the combination and use a non-interacting alternative to diltiazem. If it is unavoidable, monitor liver tests, blood counts and GI symptoms and consider reducing the bosutinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Diltiazem?
MediHelp rates the interaction as major. Bosutinib and Diltiazem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosutinib is a CYP3A4 substrate, and diltiazem is a moderate CYP3A4 inhibitor. Higher bosutinib levels raise the risk of hepatotoxicity, gastrointestinal toxicity and myelosuppression.
How serious is the interaction between Bosutinib and Diltiazem?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-interacting alternative to diltiazem. If it is unavoidable, monitor liver tests, blood counts and GI symptoms and consider reducing the bosutinib dose.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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