Drug interactions
Bosutinib + Etoposide
Severity: Moderate
Bosutinib and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib inhibits P-glycoprotein, and etoposide is a P-gp substrate, so etoposide exposure may increase. Bosutinib and etoposide can also each cause myelosuppression.
What this interaction means in plain words
Bosutinib and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Etoposide belongs to Oncology.
Why it happens
P-gp inhibition by bosutinib increases etoposide absorption and reduces its efflux, with additive myelosuppression.
What to do
Monitor complete blood counts frequently and reduce etoposide dose for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Etoposide?
MediHelp rates the interaction as moderate. Bosutinib and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib inhibits P-glycoprotein, and etoposide is a P-gp substrate, so etoposide exposure may increase. Bosutinib and etoposide can also each cause myelosuppression.
How serious is the interaction between Bosutinib and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce etoposide dose for significant cytopenias.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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